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Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
Published on: April 24, 2018
One-pot synthesis of luotonin A and its analogues
Ming-Chung Tseng1, Yu-Wan Chu, Hsiang-Ping Tsai
1Department of Chemistry and Biochemistry, National Chung Cheng University, Minhsiung, Chiayi, Taiwan, ROC.
Organic Letters
|January 28, 2011
Abstract:
Starting with inexpensive reagents, a self-directed chemical process with the aid of a single metal triflate was readily achieved to concomitantly construct quinazoline and pyrroloquinoline cores to afford the synthesis of luotonin A and its analogues. Among all compounds prepared, 2c, 2d, and 3b exhibit more potent inhibitory activity than luotonin A against human topoisomerase I.
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