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Related Experiment Video

Updated: Jun 4, 2026

Production and Measurement of Organic Particulate Matter in a Flow Tube Reactor

Production and Measurement of Organic Particulate Matter in a Flow Tube Reactor

Published on: December 15, 2018

Continuous flow ozonolysis in a laboratory scale reactor.

Muhammad Irfan¹, Toma N Glasnov, C Oliver Kappe

¹Christian Doppler Laboratory for Microwave Chemistry (CDLMC), Karl-Franzens University Graz, Graz, Austria.

Organic Letters

|January 28, 2011

Summary

Continuous flow ozonolysis and quenching reactions are now safer and scalable. This new technique enables efficient laboratory-scale ozonolysis, improving chemical synthesis safety and accessibility.

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Area of Science:

Organic Chemistry
Chemical Engineering
Reaction Engineering

Background:

Ozonolysis reactions are crucial in organic synthesis for cleaving carbon-carbon double bonds.
Traditional batch ozonolysis can pose safety risks due to the handling of ozone and exothermic reactions.
The development of continuous flow chemistry offers potential solutions for safer and more controlled reactions.

Purpose of the Study:

To develop and demonstrate a continuous flow device for performing ozonolysis reactions.
To integrate both the ozonolysis and quenching steps within a single flow system.
To establish a safe and scalable method for laboratory-scale ozonolysis.

Main Methods:

Utilized a custom-designed continuous flow reactor.
Integrated ozone generation and delivery into the flow system.
Performed ozonolysis of various substrates followed by in-line quenching.

Main Results:

Successfully executed several important types of ozonolysis reactions in flow mode.
Demonstrated the ability to perform both ozonolysis and quenching steps continuously.
Confirmed the safety and scalability of the developed flow technique for laboratory applications.

Conclusions:

The continuous flow device provides a safe and efficient platform for ozonolysis reactions.
This technique enhances the scalability of ozonolysis for laboratory synthesis.
Flow chemistry offers a promising alternative to traditional batch methods for hazardous reactions like ozonolysis.