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Fatigue

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...

Cancer

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

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Related Experiment Video

Updated: Jun 4, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

Cancer-related fatigue.

S De Waele¹, S Van Belle

¹Department of Medical Oncology, University Hospital Ghent, Ghent, Belgium. sdewaele@hotmail.com

Acta Clinica Belgica

|January 29, 2011

Summary

Cancer-related fatigue (CRF) significantly impacts quality of life. Methylphenidate, modafinil, and guarana show promise for managing CRF, but more research is needed.

Area of Science:

Oncology
Symptom Management

Background:

Cancer-related fatigue (CRF) is a prevalent and debilitating symptom in cancer patients.
CRF negatively impacts quality of life and treatment adherence.
The complex and varied pathophysiology of CRF presents management challenges.

Purpose of the Study:

To review therapeutic strategies for managing cancer-related fatigue.
To explore nonpharmacological and pharmacological interventions for CRF.
To identify promising drug candidates for CRF treatment.

Main Methods:

Literature review of contributing factors to CRF.
Analysis of nonpharmacological treatments (exercise, psychosocial interventions).
Evaluation of pharmacological agents studied for CRF management.

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Last Updated: Jun 4, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

Main Results:

Psychostimulants (methylphenidate, modafinil), L-carnitine, and guarana have been investigated.
Methylphenidate, modafinil, and guarana demonstrate the most promising results to date.
Nonpharmacological approaches like exercise and psychosocial support are also considered.

Conclusions:

Effective CRF management can reduce cancer and treatment burden.
Methylphenidate, modafinil, and guarana warrant further investigation.
Additional randomized, placebo-controlled trials are essential to confirm the efficacy of these interventions.