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Updated: Jun 4, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Cocaine-associated acute severe hyponatremia
M R Karim1, M Jawairia, S Rahman
1Division of Nephrology and Hypertension, Nassau University Medical Center, East Meadow, NY, USA.
Abstract:
Cocaine is an indirect sympathomimetic agent that acts in the nervous system to block the presynaptic reuptake of serotonin and catecholamines (dopamine, norepinephrine and epinephrine) and to increase their bioavailability at the post-synaptic receptors. The association of cocaine and hyponatremia has not been reported in adults. We describe a case of acute severe hyponatremia that followed smoking cocaine. We propose that cocaine, via its effect on the neurotransmitters, stimulates antidiuretic hormone release and leads to a syndrome of inappropriate antidiuretic hormone secretion.
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