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Related Experiment Video

Updated: Jun 4, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

Cocaine-associated acute severe hyponatremia.

M R Karim¹, M Jawairia, S Rahman

¹Division of Nephrology and Hypertension, Nassau University Medical Center, East Meadow, NY, USA.

Clinical Nephrology

|January 29, 2011

Summary

Cocaine use can cause severe hyponatremia, a dangerous drop in sodium levels. This occurs due to the drug stimulating antidiuretic hormone release, leading to syndrome of inappropriate antidiuretic hormone secretion.

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Area of Science:

Neuroscience
Toxicology
Endocrinology

Background:

Cocaine is a sympathomimetic agent blocking neurotransmitter reuptake.
Its association with hyponatremia is not previously reported in adults.

Observation:

A case of acute severe hyponatremia following cocaine smoking is presented.
This highlights a potential adverse effect of recreational cocaine use.

Findings:

Cocaine's action on neurotransmitters may stimulate antidiuretic hormone (ADH) release.
This leads to the syndrome of inappropriate antidiuretic hormone secretion (SIADH).

Implications:

Clinicians should consider SIADH in patients with hyponatremia after cocaine use.
This finding expands the known toxicology profile of cocaine.
Understanding this mechanism is crucial for managing cocaine-induced complications.