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A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Cocaine-associated acute severe hyponatremia.
M R Karim1, M Jawairia, S Rahman
1Division of Nephrology and Hypertension, Nassau University Medical Center, East Meadow, NY, USA.
Cocaine use can cause severe hyponatremia, a dangerous drop in sodium levels. This occurs due to the drug stimulating antidiuretic hormone release, leading to syndrome of inappropriate antidiuretic hormone secretion.
Area of Science:
- Neuroscience
- Toxicology
- Endocrinology
Background:
- Cocaine is a sympathomimetic agent blocking neurotransmitter reuptake.
- Its association with hyponatremia is not previously reported in adults.
Observation:
- A case of acute severe hyponatremia following cocaine smoking is presented.
- This highlights a potential adverse effect of recreational cocaine use.
Findings:
- Cocaine's action on neurotransmitters may stimulate antidiuretic hormone (ADH) release.
- This leads to the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Implications:
- Clinicians should consider SIADH in patients with hyponatremia after cocaine use.
- This finding expands the known toxicology profile of cocaine.
- Understanding this mechanism is crucial for managing cocaine-induced complications.
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