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Updated: Jun 4, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
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[Sentinel node procedure in head and neck cutaneous melanoma].

M Roche1, A Duvernay, S Dalac

  • 1Service de Chirurgie Maxillofaciale et Stomatologie, Chirurgie Plastique, Esthétique et Réparatrice, Chirurgie de la Main, CHU de Dijon, 3, rue du Faubourg-Raines, BP 1519, 21033 Dijon, France.

Revue De Stomatologie Et De Chirurgie Maxillo-Faciale
|January 29, 2011
PubMed
Summary

Sentinel lymph node (SLN) biopsy for head and neck melanoma is complex. Our study found SLN biopsy difficult to implement, with one patient experiencing complications.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Dermatology

Background:

  • Sentinel lymph node (SLN) biopsy is a debated procedure for cutaneous melanoma management.
  • SLN biopsy presents significant challenges in head and neck localizations.
  • The clinical benefits of the SLN protocol are not yet definitively proven.

Purpose of the Study:

  • To present the experience of SLN biopsy in head and neck cutaneous melanoma.
  • To evaluate the technique, implementation, and difficulties of SLN biopsy in this region.

Main Methods:

  • Retrospective study of patients with head and neck malignant melanoma (2002-2006).
  • Review of procedure technique, implementation, difficulties, outcomes, and complications.
  • Inclusion of 19 patients.

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Main Results:

  • An average of 2.2 lymph nodes were localized per patient via lymphoscintigraphy.
  • Biopsy was not possible for one patient due to an undetected deep spinal node.
  • An average of 1.2 lymph nodes were biopsied per patient.
  • One patient had micrometastases, and another experienced lymphorrhea.

Conclusions:

  • Sentinel node biopsy is widely used for melanoma but remains optional for head and neck cases per French guidelines.
  • Implementing SLN biopsy in the head and neck is challenging due to the intricate lymphatic system.
  • Further evaluation is needed to establish the definitive benefits of SLN protocol in this area.