Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Flash glucose monitoring: Impact on markers of glycaemic control and patient-reported outcomes in individuals with type 1 diabetes mellitus in the real-world setting.

Diabetes research and clinical practice·2019
Same author

Managing thymic enlargement in Graves' disease.

Endocrinology, diabetes & metabolism case reports·2019
Same author

Just another case of bacterial meningitis… or… is it?

BMJ case reports·2018
Same author

Impact of vitamin D replacement in patients with normocalcaemic and hypercalcaemic primary hyperparathyroidism and coexisting vitamin D deficiency.

Annals of clinical biochemistry·2014
Same author

Prognostic significance of thyroglobulin antibody epitopes in differentiated thyroid cancer.

The Journal of clinical endocrinology and metabolism·2014
Same author

Nephrogenic diabetes insipidus partially responsive to oral desmopressin in a subject with lithium-induced multiple endocrinopathy.

Clinical medicine (London, England)·2013
Same journal

Inhibition of TGF-β1/Smad signaling reverses the dedifferentiated phenotype of thyroid cancer cells in three-dimensional culture.

Journal of endocrinological investigation·2026
Same journal

lncRNA PANDAR predicts adverse pregnancy outcomes and reflects hyperglycemia-associated cellular stress in gestational diabetes mellitus.

Journal of endocrinological investigation·2026
Same journal

Correction: Early in, early out: reproductive lifespan timing and cardiometabolic risk in women.

Journal of endocrinological investigation·2026
Same journal

Adult mice are more susceptible to high-fat diet-induced visceral adiposity and insulin resistance than juvenile mice.

Journal of endocrinological investigation·2026
Same journal

Lactobacillus gasseri alleviates type 2 diabetes via modulation of gut microbiota-host metabolic networks.

Journal of endocrinological investigation·2026
Same journal

Rare causes of exogenous Cushing's Syndrome: a challenge for endocrinologists.

Journal of endocrinological investigation·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
05:41

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

Targeted thyroid testing in acute illness: achieving success through audit.

M A Adlan1, V Neel, S S Lakra

  • 1Section of Diabetes and Endocrinology, Department of Medicine, Caerphilly Miners' Hospital, St. Martin's Road, Caerphilly CF83 2 WW, UK. mohamed.adlan@gwent.wales.nhs.uk

Journal of Endocrinological Investigation
|January 29, 2011
PubMed
Summary
This summary is machine-generated.

Thyroid testing in acutely ill patients significantly decreased after implementing guidelines. New recommendations focus on specific patient groups to improve utility and cost-effectiveness.

More Related Videos

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Related Experiment Videos

Last Updated: Jun 4, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
05:41

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions

Published on: February 9, 2024

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

  • Internal Medicine
  • Endocrinology
  • Clinical Audit

Background:

  • Thyroid testing in acutely ill patients often yields transient abnormalities with unclear clinical utility and cost-benefit.
  • Previous practices lacked standardized guidelines for thyroid function testing in this population.

Purpose of the Study:

  • To assess the frequency, utility, and cost of thyroid testing in acutely ill patients.
  • To evaluate the impact of audit and guideline implementation on thyroid testing practices.

Main Methods:

  • Retrospective analysis of thyroid testing in the Medical Assessment Unit (MAU) in 2004.
  • Implementation of guidelines and a repeat audit in 2008.
  • Analysis of test frequency, abnormality patterns, documentation of indications, intervention, and follow-up.

Main Results:

  • Thyroid testing decreased from 53.8% in 2004 to 21.7% in 2008 (p<0.001).
  • Abnormal thyroid results (Free T4 or TSH) decreased from 11.2% to 7.5% (p=0.10), with low TSH common.
  • Documentation of appropriate indications, intervention, and follow-up significantly improved post-guidelines.

Conclusions:

  • Audit and guideline implementation effectively reduced unnecessary thyroid testing in acutely ill patients.
  • Current recommendations advocate for thyroid tests only in patients with prior thyroid disease, specific clinical features, risk factors, relevant drug use, or unexplained tachydysrhythmias.
  • Restricted thyroid testing policies are advisable due to interpretation challenges, unclear intervention benefits, and potential cost savings.