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Multiple faces of FoxM1 transcription factor: lessons from transgenic mouse models
Tanya V Kalin1, Vladimir Ustiyan, Vladimir V Kalinichenko
1Division of Pulmonary Biology and Perinatal Institute of the Cincinnati Children's Hospital Research Foundation, Cincinnati, OH, USA. Tatiana.Kalin@cchmc.org
Cell Cycle (Georgetown, Tex.)
|January 29, 2011
Summary
The FoxM1 transcription factor is vital for cell division and embryonic development. Its re-activation in adult tissues is linked to organ injury and cancer, offering potential therapeutic targets.
Area of Science:
- Molecular Biology
- Developmental Biology
- Cancer Research
Background:
- FoxM1 (previously HFH-11B, Trident, FoxM1b, Win, MPP2) is a transcription factor crucial for cell cycle progression.
- FoxM1 expression is essential during embryogenesis, with its absence causing embryonic lethality.
- FoxM1 levels decrease in adult tissues but re-emerge during organ injury and cancer development.
Purpose of the Study:
- To review the multifaceted roles of FoxM1 in various cell lineages.
- To analyze novel cell-autonomous functions of FoxM1 in embryonic development, organ injury, and cancer.
- To discuss potential diagnostic and therapeutic applications of FoxM1 research.
Main Methods:
- Analysis of data from transgenic mouse models with conditional FoxM1 gain- and loss-of-function.
- Examination of tissue samples from human patients.
- Experimental data on FoxM1 expression sites in mouse embryos.
Main Results:
- FoxM1 plays critical cell-autonomous roles in embryonic development.
- Re-activated FoxM1 is implicated in organ injury and cancer formation in vivo.
- Identified additional sites of FoxM1 expression in the developing mouse embryo.
Conclusions:
- FoxM1 is a key regulator in cell proliferation, embryonic development, and disease pathogenesis.
- Understanding FoxM1 dynamics offers avenues for novel disease diagnosis and treatment strategies.
- Conditional mouse models and human patient data provide critical insights into FoxM1 functions.
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