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Malignant pigmented villonodular synovitis in the knee - report of a case with rapid clinical progression
Naoaki Imakiire1, Takashi Fujino, Takeshi Morii
1Department of Orthopaedic Surgery, Kyorin University Faculty of Medicine. 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan.
Abstract:
Malignant pigmented villonodular synovitis (PVNS) (or malignant giant cell tumor of tendon sheath (GCTTS) is an extremely rare condition defined as a malignant lesion occurring with concomitant or previously documented PVNS at the same site. To date, only less than 20 cases have been reported in English literatures. We report a case of malignant PVNS in the knee in a 56-year-old woman with unpredictable rapid progression. This case raised a caution that when atypical components in specimens of recurrent benign PVNS are detected, even if low-grade or tiny, both pathologists and surgeons should consider the risk of malignant PVNS, which could display aggressive clinical progression.
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