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Updated: Jun 4, 2026

13:19
Chemical Triphosphorylation of Oligonucleotides
Published on: June 2, 2022
Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids
Thomas Pesnot1, Markus C Gershater, John M Ward
1Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
Abstract:
A one-pot synthesis of tetrahydroisoquinoline alkaloids in a phosphate buffer has been achieved, and a reaction mechanism proposed. The utilisation of mild reaction conditions readily afforded a range of isoquinolines, including norcoclaurine.

