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Updated: Jun 4, 2026
Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
Published on: September 7, 2021
[Cytogenetic analysis of material from spontaneous abortion]
Daniel Lorber Rolnik1, Mário Henrique Burlacchini de Carvalho, Ana Lúcia Pereira Monteiro Catelani
1Grupo Fleury Medicina & Saúde, São Paulo, SP.
Objective:
To describe chromosomal abnormalities in spontaneous abortion material.
Methods:
A retrospective compilation of karyotype analysis of slides stained with Band G was carried out by optical microscopy with materials of 428 abortion products referred for study.
Results:
There were 145 normal results (33.9%) and 237 abnormal results (55.4%). In 46 samples there was no cell growth (10.7%). Numerical abnormalities were the most frequent, especially trisomy 16 (41 cases), triplodia (27 cases), monosomy X (26 cases), tetraploidy (13 cases) and trisomy 15 (13 cases).
Conclusion:
Cytogenetic alterations are an important cause of pregnancy loss and their detection helps the genetic counseling to the couple. Trisomy 16 is the most often found change.
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