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Updated: Jun 4, 2026
05:31
Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
Published on: January 26, 2024
[Pre-eclampsia treatment according to scientific evidence]
Carlos Noronha Neto1, Alex Sandro Rolland de Souza, Melania Maria Ramos Amorim
1Saúde Materno-Infantil do Instituto de Medicina Integral Prof. Fernando Figueira – IMIP – Recife (PE), Brasil. ca.no.ne@hotmail.com
Summary
Hypertensive disorders in pregnancy, including pre-eclampsia, are a major global health concern. Early delivery and magnesium sulfate for seizures are key treatments, but more research is needed on long-term antihypertensive therapy.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Public Health
Context:
- Hypertensive disorders in pregnancy are a leading cause of maternal mortality globally and in Brazil.
- Pre-eclampsia significantly impacts maternal and fetal outcomes, with largely unknown etiology.
- Current management strategies focus on reducing high morbidity and mortality rates.
Purpose:
- To review current treatment strategies for pre-eclampsia and related hypertensive disorders in pregnancy.
- To highlight the importance of timely interventions and identify areas needing further research.
- To inform clinical practice regarding the management of severe pre-eclampsia and eclampsia.
Summary:
- Anticipation of delivery is considered the optimal treatment for pre-eclampsia.
- Magnesium sulfate is recommended for seizure prevention and treatment in severe pre-eclampsia and eclampsia.
- Antenatal corticosteroids are indicated for imminent preterm delivery (24-34 weeks); evidence for bed rest and plasma volume expansion is insufficient.
Impact:
- Provides an overview of evidence-based treatments for hypertensive disorders in pregnancy.
- Emphasizes the need for randomized clinical trials to clarify the role of maintenance antihypertensive therapy.
- Aims to improve clinical decision-making and reduce maternal and fetal complications.
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