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[Antiangiogenic therapy at the ocular surface: when, what and why?]
F Bock1, B Regenfuss, C Cursiefen
1Augenklinik mit Poliklinik, Labor für Okuläre Angiogenese, Lymphangiogenese und Transplantatimmunologie, Universität Erlangen-Nürnberg, Universitäts-Augenklinik Erlangen, Schwabachanlage 6, 91054, Erlangen, Deutschland.
Summary
Local antiangiogenic therapy shows promise for ocular surface conditions like corneal neovascularization. This review discusses its uses, treatments, and side effects for improved eye health.
Area of Science:
- Ophthalmology
- Vascular Biology
- Oncology
Context:
- Ocular surface diseases often involve abnormal blood and lymphatic vessel growth.
- Corneal neovascularization threatens vision and graft survival.
- Tumor-associated lymphangiogenesis poses risks in ocular oncology.
Purpose:
- To review indications for local antiangiogenic therapy on the ocular surface.
- To discuss current therapeutic strategies and their efficacy.
- To evaluate potential side effects of antiangiogenic treatments.
Summary:
- Local antiangiogenic therapy is indicated for vision-limiting corneal neovascularization.
- It addresses corneal blood and lymphatic vessels that endanger graft survival.
- Therapy also targets tumor-associated lymphangiogenesis.
Impact:
- Provides a comprehensive overview of antiangiogenic therapy for ocular surface conditions.
- Informs clinical practice regarding treatment options and patient selection.
- Highlights the importance of managing ocular angiogenesis for improved patient outcomes.
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