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Our experience on Actovegin, is it cutting edge?

P Lee1, A Rattenberry, S Connelly

  • 1Cardiff University, Institute of Medical Engineering and Medical Physics, Cardiff, United Kingdom. paul@medwales.com

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Actovegin may accelerate recovery for athletes with muscle injuries, allowing them to return to play 8 days sooner than with physiotherapy alone. This pilot study found no adverse reactions to Actovegin in treated athletes.

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Area of Science:

  • Sports Medicine
  • Muscle Injury Research
  • Pharmacology

Background:

  • Muscle injuries are prevalent in sports, causing significant training and match loss.
  • Actovegin (deproteinised extract) use in sports medicine is controversial, with anecdotal claims of performance enhancement.
  • Limited scientific understanding exists regarding Actovegin's effects on muscle injury recovery.

Purpose of the Study:

  • To review current evidence on Actovegin's efficacy and legal status in sports.
  • To investigate Actovegin's potential role in treating sports-related muscle injuries.
  • To report findings from a pilot study on Actovegin treatment for muscle injuries.

Main Methods:

  • Literature review of Actovegin's evidence and regulatory standing.
  • Pilot study involving athletes with muscle injuries, comparing Actovegin treatment to physiotherapy alone.
  • Data collection on return-to-play timelines and adverse events.

Main Results:

  • Athletes receiving Actovegin treatment returned to play an average of 8 days earlier than those receiving physiotherapy alone (p=0.033).
  • The study observed no adverse reactions in participants treated with Actovegin.
  • Current evidence on Actovegin's performance-enhancing capacity is limited, despite its long history of use.

Conclusions:

  • Actovegin shows potential as an adjunct therapy for accelerating muscle injury recovery in athletes.
  • Further research is warranted to elucidate Actovegin's mechanism of action and confirm its efficacy.
  • The safety profile of Actovegin in this pilot study was favorable, with no reported adverse effects.