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Potential benefits from currently available three pneumococcal vaccines for children--population-based evaluation
S Rückinger1, M van der Linden, A Siedler
1Institute of Social Pediatrics and Adolescent Medicine, Ludwig-Maximilian-University of Munich, Germany. simon.rueckinger@med.uni-muenchen.de
Klinische Padiatrie
|January 29, 2011
Summary
New pneumococcal vaccines show promise in reducing invasive pneumococcal disease (IPD) in German children. Evaluating PCV10, PCV13, and PPV23 vaccines is crucial for public health strategies.
Area of Science:
- Pediatric infectious diseases
- Vaccinology
- Public health epidemiology
Background:
- Germany offers three pneumococcal vaccines.
- Invasive pneumococcal disease (IPD) remains a concern in children.
- Evaluating vaccine impact on IPD burden is essential.
Purpose of the Study:
- Assess the potential of current pneumococcal vaccines to decrease IPD in children.
- Compare the serotype coverage of PCV10, PCV13, and PPV23 vaccines.
Main Methods:
- Study included children under 16 hospitalized with IPD in Germany (July 2007-June 2009).
- IPD surveillance in pediatric hospitals and labs used isolation of Streptococcus pneumoniae.
- Capture-recapture method estimated total IPD cases.
Main Results:
- Estimated yearly IPD cases: 164 (under 2 yrs), 144 (2-4 yrs), 116 (5-15 yrs).
- Serotypes covered by PCV10 accounted for 69 cases in <2 yrs; PCV13 covered 103 cases.
- PCV13 covered 94 cases in 2-4 yrs; PPV23 covered 108 cases.
Conclusions:
- Pneumococcal conjugate vaccines with broader serotype coverage can further reduce IPD in Germany.
- The added benefit of PPV23 vaccination for high-risk children aged 2-4 years is uncertain.
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