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Updated: Jun 4, 2026
10:46
Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models
Published on: May 3, 2017
[Memantine: the value of combined therapy]
1Hospital Clinic de Barcelona, 08036 Barcelona, Espana. jlmoli@clinic.ub.es
Revista De Neurologia
|January 29, 2011
Summary
This review examines the combined use of acetylcholinesterase inhibitors and memantine for Alzheimer's disease. Evidence is assessed to determine the effectiveness of this dual therapeutic approach in symptomatic treatment.
Area of Science:
- Neuroscience
- Pharmacology
Context:
- Alzheimer's disease (AD) symptomatic treatment currently relies on acetylcholinesterase inhibitors and memantine.
- Both drug classes target distinct mechanisms: acetylcholinesterase inhibitors block enzyme activity, while memantine modulates NMDA receptor function.
Purpose:
- To review existing evidence on the efficacy of combined acetylcholinesterase inhibitors and memantine therapy for Alzheimer's disease.
- To evaluate the potential benefits of initiating combination treatment early in the moderate disease phase (MMSE: 10-20).
Summary:
- Acetylcholinesterase inhibitors and memantine are approved for moderate AD, targeting complementary pathways.
- This review synthesizes data on the combined therapeutic approach to assess its clinical utility.
- Evidence is analyzed to discern the usefulness of initiating dual therapy from the outset.
Impact:
- Provides a comprehensive overview of combination therapy for Alzheimer's disease.
- Informs clinical decision-making regarding the optimal timing and use of combined pharmacological interventions.
- Contributes to the evidence base for managing moderate-stage Alzheimer's disease symptoms.
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