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Atom Probe Tomography Analysis of Exsolved Mineral Phases
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Published on: October 25, 2019

Atom probe tomography - a high throughput screening tool for atomic scale chemistry.

Krishna Rajan1

  • 1Department of Materials Science & Engineering, Institute for Combinatorial Discovery, Iowa State University, Ames, 50011, USA. krajan@iastate.edu

Combinatorial Chemistry & High Throughput Screening
|January 29, 2011
PubMed
Summary
This summary is machine-generated.

Atom probe tomography offers new possibilities for high-throughput screening of atomic-scale chemistry, especially for organic and biological materials. Overcoming current challenges can expand its use in combinatorial chemistry.

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Area of Science:

  • Materials Science
  • Chemistry
  • Nanotechnology

Background:

  • High-throughput screening methods are crucial for accelerating scientific discovery.
  • Current nanoscale screening often focuses on material properties, not atomic-level chemistry or structure.
  • Atom probe tomography (APT) is an advanced microscopy technique for 3D atomic-scale chemical analysis.

Purpose of the Study:

  • To explore the potential of atom probe tomography as a high-throughput screening tool for atomic-scale chemistry.
  • To identify the challenges and opportunities associated with using APT in this capacity.
  • To highlight the specific relevance and requirements for studying organic and biological materials.

Main Methods:

  • Review and analysis of existing literature on atom probe tomography and high-throughput screening.
  • Discussion of the capabilities of APT for chemical and structural analysis at the atomic scale.
  • Examination of the adaptation of APT for combinatorial chemistry workflows.

Main Results:

  • Atom probe tomography can provide high-throughput, atomic-scale chemical and structural information.
  • Significant challenges remain in sample preparation, data acquisition speed, and data analysis for widespread APT adoption.
  • APT shows particular promise for analyzing the chemistry of organic and biological materials.

Conclusions:

  • Atom probe tomography presents a significant opportunity to advance high-throughput screening of atomic-scale chemistry.
  • Addressing technical and workflow challenges is essential for integrating APT into combinatorial chemistry.
  • Further development is needed to fully realize APT's potential in materials discovery and biological sciences.