Related Experiment Video
Updated: Jun 4, 2026

Isolation and Physiological Analysis of Mouse Cardiomyocytes
Published on: September 7, 2014
Not takotsubo: a different form of stress-induced cardiomyopathy--a case series
Cho M Win1, Amit Pathak, Maya Guglin
1University of South Florida and Tampa General Hospital, Tampa, FL 33606, USA.
Insights
Stress-induced cardiomyopathy, often diagnosed by apical ballooning, can also manifest as transient global left ventricular dysfunction. This finding expands the spectrum of reversible cardiac conditions associated with severe illness.
Area of Science:
- Cardiology
- Internal Medicine
Background:
- Stress-induced cardiomyopathy (SIC) diagnosis typically relies on regional wall motion abnormalities, classically apical ballooning.
- Takotsubo cardiomyopathy is a common form of SIC.
Observation:
- Three cases of transient global left ventricular systolic dysfunction during severe medical illness are presented.
- These cases mimicked takotsubo cardiomyopathy but lacked regional wall motion abnormalities.
Findings:
- The observed cardiomyopathy showed reversibility, mild troponin elevation, non-specific ECG changes, and negative ischemia work-up.
- Global left ventricular dysfunction, distinct from regional wall motion abnormalities, is a potential presentation of SIC.
Implications:
- The spectrum of stress-induced cardiomyopathy may include global left ventricular dysfunction, not solely regional patterns.
- Recognizing global dysfunction as a variant of SIC is crucial for accurate diagnosis and management in critically ill patients.
Abstract:
The diagnosis of stress-induced cardiomyopathy requires wall motion abnormality, most typically apical ballooning. The authors report 3 cases of transient global left ventricular systolic dysfunction that developed over the course of severe medical illnesses. The cardiomyopathy that developed in each patient had all the features of takotsubo cardiomyopathy, including reversibility, mild troponin elevation, nonspecific electrocardiographic abnormalities, and a negative work-up for ischemia. The only difference was the absence of regional wall motion abnormalities. No patients developed sepsis or myocarditis. Stress-induced cardiomyopathy may present in different forms, including regional or global left ventricular dysfunction. Classic takotsubo syndrome may represent only part of the spectrum of this reversible condition.
Related Concept Videos
Cardiomyopathy I: Introduction and Classification
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Myocarditis I: Introduction
Cardiomyopathy V: Interprofessional Care
Cardiomyopathy II: Dilated Cardiomyopathy