Related Experiment Video
Updated: Jun 4, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
Alternatives to antidepressants in treating acute bipolar depression
1Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.
Abstract:
Major depressive episodes and subsyndromal depressive symptoms are associated with significant psychosocial impairment for patients with bipolar disorder. However, insufficient evidence exists to support the efficacy of antidepressants for treating bipolar depression. Alternative pharmacotherapies have been approved for the treatment of bipolar depressive episodes, and adjunctive psychosocial interventions have proven efficacy when used with pharmacotherapy.
Related Concept Videos
Mania and Antimanic Drugs: Overview
Antidepressant Drugs: MAOIs and Other Agents
Drug Therapy
Antianxiety Medications
Electroconvulsive Therapy
Psychosis: Goals of Pharmacotherapy
Bipolar Disorder