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Circulating microparticles in children with sleep disordered breathing

Jinkwan Kim1, Rakesh Bhattacharjee1, Leila Kheirandish-Gozal1

  • 1Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children's Hospital, University of Chicago, Chicago, IL; Division of Pediatric Sleep Medicine, University of Louisville School of Medicine, Louisville, KY.

Chest
|January 29, 2011
PubMed

Insights

Pediatric obstructive sleep apnea (OSA) is linked to increased cell-derived microparticles (MPs), particularly platelet-derived MPs, which may indicate heightened cardiovascular risk and altered endothelial function in children.

Area of Science:

  • Cardiovascular Research
  • Pediatric Sleep Medicine
  • Biomarker Discovery

Background:

  • Pediatric obstructive sleep apnea (OSA) is a significant risk factor for endothelial dysfunction.
  • Circulating cell-derived microparticles (MPs) are emerging as key biomarkers for endothelial dysfunction and atherosclerosis.

Purpose of the Study:

  • To investigate the association between OSA severity in children and circulating microparticle levels.
  • To explore the relationship between specific microparticle types and endothelial function markers.

Main Methods:

  • Children with OSA underwent blood draws post-sleep study for plasma microparticle analysis via flow cytometry.
  • Endothelial function was assessed using a modified hyperemic test.
  • Levels of endothelial, endothelial progenitor, leukocyte, and platelet MPs were quantified.

Main Results:

  • Microparticle levels (endothelial, endothelial progenitor, leukocyte, platelet) varied significantly with OSA severity.
  • Leukocyte and platelet MPs correlated with the apnea-hypopnea index (AHI).
  • Specific MPs showed associations with BMI z-score, apolipoprotein B, and LDL cholesterol, and independently with AHI.

Conclusions:

  • Childhood OSA is associated with elevated circulating MP levels, potentially increasing cardiovascular risk.
  • Platelet-derived MPs are significantly linked to vascular dysfunction in pediatric OSA.
  • Further research is needed to establish MPs as reliable clinical biomarkers for vascular risk in children.
Abstract

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