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Updated: Jun 4, 2026

Breath Collection from Children for Disease Biomarker Discovery

Breath Collection from Children for Disease Biomarker Discovery

Published on: February 14, 2019

Circulating microparticles in children with sleep disordered breathing.

Jinkwan Kim¹, Rakesh Bhattacharjee¹, Leila Kheirandish-Gozal¹

¹Section of Pediatric Sleep Medicine, Department of Pediatrics, Comer Children's Hospital, University of Chicago, Chicago, IL; Division of Pediatric Sleep Medicine, University of Louisville School of Medicine, Louisville, KY.

|January 29, 2011

Summary

Pediatric obstructive sleep apnea (OSA) is linked to increased cell-derived microparticles (MPs), particularly platelet-derived MPs, which may indicate heightened cardiovascular risk and altered endothelial function in children.

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Area of Science:

Cardiovascular Research
Pediatric Sleep Medicine
Biomarker Discovery

Background:

Pediatric obstructive sleep apnea (OSA) is a significant risk factor for endothelial dysfunction.
Circulating cell-derived microparticles (MPs) are emerging as key biomarkers for endothelial dysfunction and atherosclerosis.

Purpose of the Study:

To investigate the association between OSA severity in children and circulating microparticle levels.
To explore the relationship between specific microparticle types and endothelial function markers.

Main Methods:

Children with OSA underwent blood draws post-sleep study for plasma microparticle analysis via flow cytometry.
Endothelial function was assessed using a modified hyperemic test.
Levels of endothelial, endothelial progenitor, leukocyte, and platelet MPs were quantified.

Main Results:

Microparticle levels (endothelial, endothelial progenitor, leukocyte, platelet) varied significantly with OSA severity.
Leukocyte and platelet MPs correlated with the apnea-hypopnea index (AHI).
Specific MPs showed associations with BMI z-score, apolipoprotein B, and LDL cholesterol, and independently with AHI.

Conclusions:

Childhood OSA is associated with elevated circulating MP levels, potentially increasing cardiovascular risk.
Platelet-derived MPs are significantly linked to vascular dysfunction in pediatric OSA.
Further research is needed to establish MPs as reliable clinical biomarkers for vascular risk in children.