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A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Cortactin in breast cancer: analysis with tissue microarray.

Shyr-Ming Sheen-Chen¹, Chun-Ying Huang, Yu-Yin Liu

¹Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Niao-Sung Hsiang, Kaohsiung Hsien, Taiwan. smsheen@yahoo.com

Anticancer Research

|January 29, 2011

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Cortactin expression in breast cancer tissues was analyzed using tissue microarray (TMA). Results indicate cortactin levels do not predict patient survival, suggesting it lacks prognostic value in breast cancer.

Area of Science:

Oncology
Molecular Pathology
Biomarker Research

Background:

Tissue microarray (TMA) enables high-throughput immunohistochemical analysis of numerous tissue samples.
Cortactin is a protein implicated in cell motility and invasion, relevant to cancer progression.

Purpose of the Study:

To evaluate cortactin expression levels in breast cancer tissues.
To determine the prognostic significance of cortactin expression in breast cancer patients.

Main Methods:

Analysis of cortactin expression using TMA in 99 primary invasive breast cancer specimens.
Correlation of cortactin levels with clinicopathological parameters including age, ER status, grade, and TNM stage.

Main Results:

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Cortactin expression varied, with 23.2% low, 60.6% intermediate, and 16.2% strong expression.

No significant association was found between cortactin expression and clinicopathological factors or survival.

Estrogen receptor status and TNM staging were significant predictors of five-year survival.

Conclusions:

Cortactin expression does not appear to have prognostic value in breast cancer.
Further research may be needed to explore other roles of cortactin in breast cancer biology.