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Published on: April 22, 2019
Successful S-1 monotherapy for chemorefractory thymic carcinoma
Tomonobu Koizumi1, Toshihiko Agatsuma, Yoshimichi Komatsu
1Comprehensive Cancer Center, Division of Clinical Oncology, Shinshu University Hospital, Asahi Matsumoto, Japan. tomonobu@shinshu-u.ac.jp
Abstract:
The optimal chemotherapeutic regimen for inoperable thymic carcinoma remains uncertain and little information is available regarding the usefulness of salvage chemotherapy. S-1, a newly developed oral fluorouracil antitumor drug, has been reported to be effective in the treatment of gastrointestinal tumors and non-small cell lung cancer. This case study reports a case of chemorefractory thymic cancer with a good response to S-1 monotherapy. S-1 was used as sixth-line chemotherapy and the response was the first remarkable tumor regression in the patient's clinical course. S-1 appears to have significant activity against thymic carcinoma.
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