Innovative sunscreen formulation based on benzophenone-3-loaded chitosan-coated polymeric nanocapsules

Area of Science:

• Nanotechnology
• Materials Science
• Dermatology

Background:

• Benzophenone-3 is a common UV filter in sunscreens.
• Nanoparticle formulations can improve sunscreen delivery and efficacy.
• Understanding skin penetration is crucial for sunscreen safety and performance.

Purpose of the Study:

• To investigate the impact of cationic chitosan coating on polymeric nanocapsules.
• To evaluate the in vitro skin penetration of benzophenone-3 (BP-3) using these nanocapsules.
• To assess the potential of this formulation for improved sunscreen applications.

Main Methods:

• Poly(ε-caprolactone) nanocapsules loaded with benzophenone-3 were synthesized.
• Nanocapsules were coated with chitosan, and characterized for size and zeta potential.
• In vitro skin penetration studies were conducted using Franz cells and porcine skin.

Main Results:

• Chitosan-coated nanocapsules exhibited a larger size (202 nm) and positive zeta potential (+21 mV) compared to uncoated ones (-8 mV).
• Formulations with coated nanocapsules showed reduced benzophenone-3 penetration into the skin.
• Higher concentrations of benzophenone-3 remained on the skin surface with the coated nanocapsule formulation.

Conclusions:

• Chitosan-coated nanocapsules effectively limit benzophenone-3 skin penetration.
• This innovative hydrogel formulation offers a promising approach to enhance sunscreen performance.
• The study suggests a potential solution for improving the daily use and efficacy of sunscreens.