Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...
Retarders01:19

Retarders

Retarders are chemical admixtures designed to extend the setting time, which is especially useful when there is a delay in sequential concrete pours to prevent cold joints and to achieve a cohesive structure. Retarders, when used in appropriate amounts, can also enhance the architectural appearance of exposed aggregate finishes.
The function of retarders is to delay the setting of concrete, and this effect can be measured using a penetration test. The retardation process involves adding...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
Pharmacokinetic–Pharmacodynamic Relationship: Problems01:24

Pharmacokinetic–Pharmacodynamic Relationship: Problems

The empirical approach to drug therapy optimization relies on correlating pharmacological response with administered dosage. Such an approach can be costly, time-consuming, and often yields poor correlation due to variables like formulation factors and drug elimination characteristics. A more precise approach correlates response with plasma drug concentration or the amount of drug in the body, rather than dosage. This is achieved through pharmacokinetic-pharmacodynamic (PK/PD) modeling, which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recent Advances in the Treatment of Isosexual Precocious Puberty: Identifying all the problems.

Canadian family physician Medecin de famille canadien·2010
Same author

Genetic risk factors in diabetic retinopathy.

Diabetologia·1993
Same author

Interaction between T cell receptor beta chain and immunoglobulin heavy chain region genes in susceptibility to insulin-dependent diabetes mellitus.

American journal of human genetics·1991
Same author

Predisposing effect of anti-beta cell autoimmune process in NOD mice on the induction of diabetes by environmental insults.

Diabetologia·1990
Same author

Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet cell autoantibody.

Diabetologia·1990
Same author

EMG-syndrome and hypothyroidism.

Clinical genetics·1989

Related Experiment Video

Updated: Jun 4, 2026

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations
05:04

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations

Published on: February 2, 2024

Growth retardation: an approach to management.

R G McArthur

    Canadian Family Physician Medecin De Famille Canadien
    |January 29, 2011
    PubMed
    Summary

    Pediatricians frequently encounter children with short stature or growth failure. This guide outlines common causes and a simple management approach, focusing on timely investigation and appropriate treatment.

    Area of Science:

    • Pediatric Endocrinology
    • Growth and Development

    Background:

    • Short stature and growth failure are common clinical challenges in pediatric practice.
    • Evaluating the extent and timing of investigations is a key concern for physicians.

    Purpose of the Study:

    • To identify common causes of growth failure in children and adolescents.
    • To outline a practical, percentile-based approach to assessment and management.
    • To emphasize the importance of treating organic causes and providing psychologic support.

    Main Methods:

    • Assessment based on established height percentiles.
    • Identification of common etiological factors contributing to growth failure.
    • Development of a simplified management strategy.

    More Related Videos

    Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
    04:22

    Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

    Published on: May 30, 2025

    Multidisciplinary Approach to Obesity Management: A Case Report
    05:10

    Multidisciplinary Approach to Obesity Management: A Case Report

    Published on: May 30, 2025

    Related Experiment Videos

    Last Updated: Jun 4, 2026

    Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations
    05:04

    Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations

    Published on: February 2, 2024

    Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
    04:22

    Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

    Published on: May 30, 2025

    Multidisciplinary Approach to Obesity Management: A Case Report
    05:10

    Multidisciplinary Approach to Obesity Management: A Case Report

    Published on: May 30, 2025

    Main Results:

    • Common causes of growth failure are systematically identified.
    • A practical framework for investigation and management is presented.
    • The dual aims of organic treatment and psychologic support are highlighted.

    Conclusions:

    • A structured approach to evaluating short stature in children is essential.
    • Timely diagnosis and treatment of underlying organic causes improve outcomes.
    • Psychologic support is a crucial component of managing growth failure.