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Ghrelin levels in children with constitutional delay of growth and puberty

Tolta Altuğ Sen1, Damla Gökşen Şimşek, Sükran Darcan

  • 1Afyon Kocatepe University, Faculty of Medicine, Department of Pediatrics, Afyonkarahisar, Turkey. tolgasen69@yahoo.com

Journal of Clinical Research in Pediatric Endocrinology
|January 29, 2011
PubMed

Insights

Ghrelin levels did not differ in children with constitutional delay of growth and puberty (CDGP), indicating appetite issues are not linked to ghrelin in this condition. Ghrelin did not increase to compensate for feeding problems in CDGP.

Area of Science:

  • Pediatric Endocrinology
  • Growth and Development Disorders
  • Hormonal Regulation

Background:

  • Constitutional delay of growth and puberty (CDGP) is a common cause of short stature in children.
  • Ghrelin, a hormone, plays a role in appetite regulation and growth.
  • The role of ghrelin in the pathophysiology of CDGP remains unclear.

Purpose of the Study:

  • To investigate the role of ghrelin in children experiencing growth delay associated with CDGP.
  • To compare ghrelin levels in children with CDGP to those of healthy controls.

Main Methods:

  • A study group of 30 male children with CDGP was compared to 15 healthy children.
  • Fasting and postprandial plasma ghrelin levels were measured.
  • Serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) levels were also determined.

Main Results:

  • No significant differences were found in fasting or postprandial ghrelin levels between children with CDGP and controls.
  • Serum IGF-1 levels were significantly lower in children with CDGP compared to the control group.
  • Ghrelin levels did not show compensatory increases in children with CDGP.

Conclusions:

  • Decreased appetite and feeding problems in CDGP are not associated with depressed ghrelin levels.
  • Ghrelin does not appear to play a compensatory role in managing appetite issues in children with CDGP.
Abstract

Keywords:
IGF−1constitutional delay of growth and pubertyghrelin

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