Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in peripheral chemoreflex sensitivity during sustained, isocapnic hypoxia.

D A Bascom1, I D Clement, D A Cunningham

  • 1University Laboratory of Physiology, Oxford, U.K.

Respiration Physiology
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quality assessment of online patient information on upper gastrointestinal endoscopy using the modified Ensuring Quality Information for Patients tool.

Annals of the Royal College of Surgeons of England·2024
Same author

Reliability of TMS metrics in patients with chronic incomplete spinal cord injury.

Spinal cord·2016
Same author

Models to Tailor Brain Stimulation Therapies in Stroke.

Neural plasticity·2016
Same author

Adequacy of diagnostic tests and surgical management of symptomatic invasive lobular carcinoma of the breast.

Annals of the Royal College of Surgeons of England·2015
Same author

Pubertal development in ICSI children.

Human reproduction (Oxford, England)·2012
Same author

Can intravenous endothelin-1 be used to enhance hypoxic pulmonary vasoconstriction in healthy humans?

British journal of anaesthesia·2008
Same journal

Braking of expiratory airflow in obese pigs during wakefulness and sleep.

Respiration physiology·2002
Same journal

Arousal response to hypoxia in newborn mice.

Respiration physiology·2002
Same journal

The oxygen gain of diving insects.

Respiration physiology·2002
Same journal

The role of endothelin-1 in strain-related susceptibility to develop hypoxic pulmonary hypertension in rats.

Respiration physiology·2002
Same journal

Active glottal closure during anoxic gasping in lambs.

Respiration physiology·2002
Same journal

Avian intrapulmonary chemoreceptor discharge rate is increased by anion exchange blocker 'DIDS'.

Respiration physiology·2002
See all related articles

Hypoxic ventilatory decline may originate peripherally. This study found that sustained hypoxia reduced the ventilatory response to hypoxia more than to carbon dioxide, suggesting peripheral chemoreceptor involvement.

Area of Science:

  • Physiology
  • Respiratory Control
  • Hypoxia Research

Background:

  • The ventilatory decline during sustained hypoxia is hypothesized to stem from central nervous system depression of peripheral chemoreflexes.
  • Understanding the precise origin of this decline is crucial for managing respiratory conditions.

Purpose of the Study:

  • To investigate changes in peripheral chemoreflex loop activity during sustained, isocapnic hypoxia.
  • To differentiate between central and peripheral contributions to hypoxic ventilatory decline.

Main Methods:

  • Measurements of ventilatory responses to hypoxia and carbon dioxide pulses during a 23-minute period of sustained isocapnic hypoxia (50 Torr) in humans.
  • Assessing responses at multiple time points (minutes 2, 7, 12, and 17) during the hypoxic exposure.

Related Experiment Videos

Main Results:

  • The ventilatory response to hypoxic stimuli significantly decreased over the 23-minute period (130% to 74%).
  • The ventilatory response to carbon dioxide stimuli also decreased, but to a lesser extent (101-103% to 91%).
  • The differential decline suggests a greater impact on hypoxic sensitivity compared to carbon dioxide sensitivity.

Conclusions:

  • The findings indicate a decline in peripheral sensitivity to hypoxia during sustained exposure.
  • This suggests that peripheral chemoreceptors, rather than central mechanisms, are the primary drivers of hypoxic ventilatory decline.
  • The results support a peripheral origin for the observed ventilatory decline under hypoxic conditions.