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Published on: June 26, 2013
Neuroimaging in Parkinson's disease
1Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, British Columbia, Canada. jstoessl@interchange.ubc.ca
Summary
Parkinson's disease (PD) involves dopamine deficiency, detectable through advanced imaging techniques. These methods assess neurochemical changes, aiding diagnosis and understanding treatment effects in PD patients.
Area of Science:
- Neuroscience
- Neurology
- Radiology
Background:
- Parkinson's disease (PD) is characterized by dopamine deficiency.
- Structural imaging shows limited changes in PD.
- Functional neuroimaging reveals significant abnormalities.
Purpose of the Study:
- To review neurochemical and metabolic imaging studies in Parkinson's disease.
- To assess dopaminergic and other neurotransmitter functions.
- To highlight clinical applications of these imaging techniques.
Main Methods:
- Positron emission tomography (PET).
- Single photon emission computed tomography (SPECT).
- Functional magnetic resonance imaging (fMRI).
Main Results:
- Neuroimaging detects abnormalities reflecting disease processes or compensatory responses.
- These changes can be linked to motor and non-motor complications.
- Imaging aids in understanding treatment interventions.
Conclusions:
- Functional neuroimaging is crucial for understanding Parkinson's disease pathology.
- These techniques offer diagnostic utility and insights into disease progression.
- Neuroimaging helps evaluate therapeutic strategies for PD.
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