Related Experiment Video

Updated: Jun 4, 2026

Implantation Protocol of the Foldable Capsular Vitreous Body for Complex Vitreoretinal Surgery
04:36

Implantation Protocol of the Foldable Capsular Vitreous Body for Complex Vitreoretinal Surgery

Published on: April 14, 2026

Vitreous web after pars plana vitrectomy and bevacizumab with fluid-air exchange

Allen Chiang1, Shantan Reddy, Irena Tsui

  • 1Department of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles, CA 90095, USA.

Seminars in Ophthalmology
|February 1, 2011
PubMed
Abstract

Insights

Intraocular inflammation after intravitreal bevacizumab can mimic infection. A unique web-like inflammatory response was observed post-operatively, resolving spontaneously without treatment.

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Surgical Complications

Background:

  • Intravitreal bevacizumab is used for retinal conditions but can cause intraocular inflammation.
  • Inflammation can be infectious or non-infectious, requiring accurate diagnosis to avoid unnecessary treatment.

Observation:

  • A case report details a patient with diabetic retinopathy, macular edema, and epiretinal membrane.
  • The patient received intraoperative intravitreal bevacizumab during pars plana vitrectomy and related procedures.
  • Wide-field fundus photography documented a distinct web-like inflammatory response in the vitreous.

Findings:

  • Post-operative day one revealed vitreous opacities forming a web-like structure.
  • Minimal anterior chamber or vitreous cell was present, suggesting a sterile inflammatory process.
  • The inflammatory reaction completely resolved within one week.

Implications:

  • This case highlights a specific sterile inflammatory pattern following intravitreal bevacizumab.
  • Differentiating this sterile inflammation from infectious endophthalmitis is crucial for appropriate patient management.
  • Wide-field imaging aids in characterizing and monitoring such post-operative inflammatory responses.

More Related Videos

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases11:20

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases

Published on: June 14, 2021

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...