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Related Experiment Video

Updated: Jun 4, 2026

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
06:42

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications

Published on: September 2, 2025

PET-guided breast biopsy.

Judith E Kalinyak1, Kathy Schilling, Wendie A Berg

  • 1Naviscan Inc., San Diego, California, USA. jkalinyak@naviscan.com

The Breast Journal
|February 1, 2011
PubMed
Summary
This summary is machine-generated.

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High-resolution positron emission mammography (PEM) with biopsy guidance software safely and effectively samples suspicious breast lesions. This advanced imaging technique improves diagnostic accuracy for breast cancer detection.

Area of Science:

  • Oncology
  • Radiology
  • Medical Imaging

Background:

  • Positron emission tomography (PET) is crucial for malignancy evaluation but has limitations in breast cancer due to low FDG uptake and small lesion size.
  • Biopsy guidance under PET has been a challenge, hindering its full potential in breast cancer diagnosis.

Purpose of the Study:

  • To evaluate the efficacy and safety of high-resolution positron emission mammography (PEM) with biopsy guidance software.
  • To assess PEM's ability to accurately target and sample FDG-avid breast lesions suspicious for malignancy.

Main Methods:

  • A prospective, multicenter study involving 19 subjects undergoing 24 vacuum-assisted core biopsies guided by PEM.
  • Lesion targeting and sampling were confirmed by post-biopsy imaging, specimen imaging, and pathologic concordance.

Related Experiment Videos

Last Updated: Jun 4, 2026

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications
06:42

Optimization of Breast Biopsy and Mastectomy Sample Collection Procedures for Biobanking, Personalized Medicine, and Research Applications

Published on: September 2, 2025

Main Results:

  • All 24 lesions were successfully targeted and sampled.
  • Invasive cancer was identified in 54% of lesions, with 17% being high-risk and 3 of these upgraded to malignancy upon excision.
  • The procedure was safe, with no serious adverse events and minimal patient discomfort.

Conclusions:

  • High-resolution PEM-guided breast biopsy is a safe and effective method for sampling PET-depicted breast lesions.
  • PEM addresses previous limitations of PET in breast cancer evaluation, offering improved diagnostic capabilities.