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Related Concept Videos

Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...

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Patch Angioplasty in the Rat Aorta or Inferior Vena Cava
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Current usage and future directions for the bovine pericardial patch.

Xin Li1, Yuanyuan Guo, Kenneth R Ziegler

  • 1Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

Annals of Vascular Surgery
|February 1, 2011
PubMed
Summary

Bovine pericardium (BP) patches are common in cardiovascular surgery but can lead to complications like restenosis and thrombosis. Further research into BP healing mechanisms is needed for improved surgical patch development.

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Area of Science:

  • Biomaterials Science
  • Cardiovascular Surgery
  • Tissue Engineering

Background:

  • Bovine pericardium (BP) is a widely used surgical patch in cardiovascular procedures, particularly after arteriotomy.
  • BP offers advantages over prosthetic patches, including biocompatibility and ease of handling.
  • Despite benefits, BP patches in carotid endarterectomy (CEA) are associated with long-term complications such as restenosis, pseudoaneurysm, and thrombosis.

Purpose of the Study:

  • To review the clinical outcomes of bovine pericardium patches used in carotid endarterectomy.
  • To identify complications associated with BP patches that may impact long-term efficacy.
  • To highlight the need for understanding BP healing mechanisms for developing improved surgical materials.

Main Methods:

  • Literature review of clinical results following carotid endarterectomy using bovine pericardium patches.
  • Analysis of reported complications including restenosis, pseudoaneurysm, infection, fibrosis, calcification, and thrombosis.
  • Identification of potential areas for improvement in surgical patch technology.

Main Results:

  • Bovine pericardium patches, while advantageous, are linked to significant long-term complications after CEA.
  • Complications such as restenosis, pseudoaneurysm, and thrombosis can reduce the effectiveness of CEA.
  • The identified issues underscore the need for enhanced surgical patch materials.

Conclusions:

  • Long-term use of bovine pericardium patches in CEA presents challenges that necessitate further investigation.
  • Understanding the biological response and healing of BP is crucial for designing next-generation tissue-engineered patches.
  • Improvements in patch technology could enhance the durability and success of cardiovascular surgeries.