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Related Experiment Video

Updated: Jun 4, 2026

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice
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The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice

Published on: February 4, 2015

Evaluation of object-based attention in mice.

Tursun Alkam1, Masayuki Hiramatsu, Takayoshi Mamiya

  • 1Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya 468-8503, Japan.

Behavioural Brain Research
|February 1, 2011
PubMed
Summary

Researchers developed a novel object-based attention task for rapid preclinical screening of attention-improving drugs in mice. This method effectively identified attention deficits induced by p-chlorophenylalanine (pCPA) and phencyclidine, aiding drug discovery.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Attention deficits significantly impair daily functioning.
  • Pharmacological interventions are key treatments, but large-scale preclinical screening methods are limited.
  • Developing efficient screening tools is crucial for identifying novel attention-improving drugs.

Purpose of the Study:

  • To develop and validate a simple, practical object-based attention task for large-scale preclinical drug screening in mice.
  • To assess the task's sensitivity to neurochemical alterations and attention deficits induced by specific pharmacological agents.

Main Methods:

  • Developed an object-based attention task for mice.
  • Administered p-chlorophenylalanine (pCPA) to induce neurochemical changes and assessed attention and memory.

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Last Updated: Jun 4, 2026

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Published on: February 4, 2015

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
08:52

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice

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Novel Object Recognition and Object Location Behavioral Testing in Mice on a Budget
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  • Validated the task using phencyclidine-induced attention deficits in a mouse model.

    • Main Results:

    • pCPA treatment reduced prefrontal serotonin and dopamine, impacting attention and working memory.
    • The object-based attention task detected deficits in novel object recognition under specific exposure conditions.
    • The task successfully identified attention deficits in a phencyclidine-induced model, confirming its validity.

    Conclusions:

    • The object-based attention task is a practical and effective method for preclinical screening of attention-improving drugs.
    • This task can aid in the behavioral assessment of compounds targeting attention and related cognitive functions.
    • The developed task facilitates the drug discovery pipeline for neurological and psychiatric disorders characterized by attention deficits.