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Updated: Jun 4, 2026

Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation
Published on: September 16, 2018
A new coumestan with immunosuppressive activities from Flemingia philippinensis
Li Li1, Xueyang Deng, Lixia Zhang
1Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China.
Abstract:
A new coumestan, 1,3,9-trihydroxy-8-methoxycoumestan, named flemicoumestan A 1 together with nine isoflavone-related compounds were isolated from the ethyl acetate extract of the roots of Flemingia philippinensis. Their structures were elucidated and confirmed by spectroscopic methods and literature data. Compounds 3 and 4 showed strong lymphocyte proliferation inhibitory activity with an IC(50) value of 1.04-2.76 μM, and the low cytotoxicity with the CC(50) value of 71.01 and 56.36 μM, respectively.
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