In vitro antimicrobial activity of econazole and miconazole sulfosalicylate

The in vitro activities of new sulfosalicylic salts of econazole (E.SSA) and miconazole (M.SSA) have been investigated in comparison with the respective nitrate (NIT) salts and sulfosalicylic acid (SSA) alone. The results reveal good antimicrobial activity of M.SSA and E.SSA against different strains of Candida, dermatophytes, moulds, Gram-positive bacteria and Trichomonas vaginalis. The MIC values demonstrate that M.SSA is more active than M.NIT on Candida and T. vaginalis. E.SSA was also more active than E.NIT on T.vaginalis. Both SSA and sodium sulfosalicylate (NaSSA) were practically without activity by themselves. Finally, the pH variations did not significantly modify the activity of the SSA salts, suggesting that their greater activity could be due to better lipophilic activity of these compounds with respect to the nitrate salts.