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Iodide-induced hypothyroidism in patients after thyroid resection.
O H Clark1, R R Cavalieri, C Moser
1Surgical Service, Veterans Administration Medical Center, San Francisco, CA 94121.
European Journal of Clinical Investigation
|December 1, 1990
Summary
Iodide administration can induce hypothyroidism even in normal thyroid tissue, not just in those with existing defects. This occurs due to increased thyroid-stimulating hormone (TSH) levels, impacting thyroid hormone production.
Area of Science:
- Endocrinology
- Thyroidology
Background:
- Iodide-induced hypothyroidism is a known condition.
- The role of pre-existing thyroid defects in its development is unclear.
Purpose of the Study:
- To investigate if iodide-induced hypothyroidism develops in normal thyroid tissue stimulated by elevated thyroid-stimulating hormone (TSH).
Main Methods:
- Euthyroid patients (post-thyroidectomy and controls) received daily iodide (180 mg) for 3-4 months.
- Serum TSH, T4, T3, and total iodine levels were monitored.
Main Results:
- All subjects showed increased serum TSH during iodide administration.
- TSH increased into the abnormal range in most post-thyroidectomy patients and some controls.
- Five post-thyroidectomy patients developed mild hypothyroidism symptoms; T4/T3 levels decreased.
- Two control patients showed slight decreases in T4.
Conclusions:
- Iodide can induce hypothyroidism in TSH-stimulated normal thyroid tissue.
- An intrinsic defect is not always required for iodide-induced hypothyroidism.