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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
[Diversity of incidence trend patterns: implications for carcinogenesis?]
G Buiret1, G Launoy, L Remontet
1Service de Biostatistique des Hospices Civils de Lyon, Bat 4D, Centre Hospitalier Lyon Sud, 69495 Pierre-Bénite, France. guillaume.buiret@laposte.net
Revue Des Maladies Respiratoires
|February 1, 2011
Summary
Alcohol and tobacco-related cancers, including those of the head and neck, esophagus, and lung, exhibit distinct spatio-temporal incidence trends. These groupings suggest varied biological responses and risk factor sensitivities.
Area of Science:
- Epidemiology
- Cancer Research
- Public Health
Context:
- Alcohol and tobacco are primary risk factors for head and neck, esophageal, and lung cancers.
- Cancer incidence patterns can vary significantly across time and geographic regions.
- Understanding these variations is crucial for targeted public health interventions.
Purpose:
- To identify distinct groups of cancers that share similar spatio-temporal incidence trends.
- To analyze incidence data for ten cancer types across six French departments from 1982 to 2002.
- To investigate how risk factors like alcohol and tobacco may influence cancer trends differently.
Summary:
- Three distinct groups of cancers with similar spatio-temporal incidence trends were identified using an age-cohort random-effect model.
- Group 1: Oral cavity, oropharynx, hypopharynx, larynx, esophagus, and lung squamous cell carcinomas showed decreasing incidence.
- Group 2: Other lung cancers and adenocarcinomas showed increasing incidence, while Group 3 (large- and small-cell lung carcinomas) displayed heterogeneous trends.
Impact:
- The identified cancer groupings suggest differences in latency periods and sensitivities to alcohol and tobacco.
- This epidemiological classification aids in understanding the complex relationship between risk factors and cancer development.
- Findings can inform more precise public health strategies for cancer prevention and control.
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