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Updated: Jun 4, 2026
07:41
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
Gene profiling in breast cancer: time to move forward
Enrique Espinosa1, Juan Ángel Fresno Vara, Iker Sánchez Navarro
1Service of Oncology, Hospital La Paz & Instituto de Investigación Sanitaria IdiPAZ, Paseo de la Castellana, Madrid, Spain. eespinosa00@terra.es
Cancer Treatment Reviews
|February 1, 2011
Summary
Gene signatures can improve breast cancer prognosis and treatment selection. Integrating these gene profiles into clinical trials is key for routine adoption and targeted drug development.
Area of Science:
- Oncology
- Genomics
- Translational Medicine
Background:
- Gene signatures offer prognostic and predictive value in breast cancer, aiding in tumor sub-classification.
- Several prognostic gene signatures are commercially available, with two progressing to phase III trials.
- Predictive signatures for drug response are under development, highlighting the potential of gene profiling.
Purpose of the Study:
- To explore the role of gene signatures in breast cancer prognosis and therapy.
- To discuss the integration of gene signatures into clinical decision-making and drug development.
- To address barriers to the widespread adoption of gene profiling in routine clinical practice.
Main Methods:
- Review of current literature on gene signatures in breast cancer.
- Analysis of the clinical utility and limitations of gene profiling technologies.
- Discussion of the future integration of gene signatures in clinical trials and practice.
Main Results:
- Gene signatures can complement traditional factors for predicting breast cancer outcomes and treatment response.
- Commercial prognostic signatures are advancing, and predictive signatures are being evaluated for specific therapies.
- The combined use of different types of gene signatures holds promise for personalized medicine in breast cancer.
Conclusions:
- Gene signatures have the potential to guide therapeutic decisions and facilitate targeted drug development in specific breast cancer patient groups.
- Cost-utility and technical limitations currently hinder widespread adoption of gene profiling.
- Inclusion of gene signatures in clinical trial designs is a crucial step towards their routine clinical integration.
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