Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cefonicid distribution into tonsillar tissue.

F Scaglione1, M Falchi, F Ferrara

  • 1Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.

International Journal of Clinical Pharmacology Research
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Normal life expectancy after all-trans retinoic acid and arsenic trioxide for acute promyelocytic leukemia.

Leukemia·2026
Same author

Exercise pulmonary hypertension in asymptomatic patients with HIV infection Insights from the RIGHT-NET registry.

European journal of internal medicine·2026
Same author

Pharmacological and speech-language pathology management of dysphagia in patients with myasthenia gravis.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same author

The sustainability of hypercholesterolemia treatment: New drugs have made such therapy more expensive.

Hipertension y riesgo vascular·2025
Same author

Comparison and analysis of biological drug consumption in two Italian hospital settings: Governance actions and prescribing appropriateness.

Journal of healthcare quality research·2025
Same author

Meatal stenosis and lichen sclerosus in children: is it a real risk? A single-centre retrospective observational study.

Annals of the Royal College of Surgeons of England·2025
Same journal

Breath alcohol concentrations in Japanese outpatients following paclitaxel and docetaxel infusion.

International journal of clinical pharmacology research·2006
Same journal

Effects of ranitidine on quality of gastric ulcer healing compared with famotidine: a randomized, controlled, multicenter trial.

International journal of clinical pharmacology research·2006
Same journal

The effect of D-003 (10 mg/day) on biochemical parameters of bone remodelling in postmenopausal women: a randomized, double-blind study.

International journal of clinical pharmacology research·2006
Same journal

Evaluation of cytokine serum levels in patients with plaque-type psoriasis.

International journal of clinical pharmacology research·2006
Same journal

Treatment of guttate psoriasis with a new two-compound product containing calcipotriol and betamethasone dipropionate.

International journal of clinical pharmacology research·2006
Same journal

Etanercept for psoriasis: two case reports.

International journal of clinical pharmacology research·2006
See all related articles

Cefonicid antibiotic levels were studied in tonsil tissue and blood of 30 patients. Peak cefonicid concentrations in tonsils were observed 3 hours post-injection, indicating effective tissue penetration.

Area of Science:

  • Pharmacokinetics
  • Infectious Diseases
  • Otolaryngology

Background:

  • Understanding antibiotic distribution in target tissues is crucial for effective treatment of infections.
  • Tonsillar infections often require antibiotic therapy, necessitating knowledge of drug penetration into this specific tissue.

Purpose of the Study:

  • To investigate the pharmacokinetic profile of cefonicid in human tonsil tissue.
  • To determine cefonicid serum and tonsil concentrations over a 24-hour period following intramuscular administration.

Main Methods:

  • A single intramuscular dose of 1g cefonicid was administered to 30 patients undergoing tonsillectomy.
  • Blood and tonsil tissue samples were collected at various time points (1, 2, 3, 6, 12, and 24 hours).
  • Antibiotic concentrations were quantified using a microbiological assay.

Related Experiment Videos

Main Results:

  • Peak serum cefonicid levels (94.2 ± 9.83 mg/l) were achieved at 1 hour post-administration.
  • Peak tonsil tissue concentrations (11.9 ± 3.68 mg/kg) were observed at 3 hours.
  • Detectable cefonicid levels remained in tonsil tissue up to 24 hours post-dose.

Conclusions:

  • Cefonicid demonstrates favorable pharmacokinetic properties with significant penetration into tonsil tissue.
  • The observed tissue concentrations suggest cefonicid's potential efficacy in treating tonsillar infections.