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Predialysis chronic kidney disease in 2010: Novel targets for slowing CKD progression

Juan Jesús Carrero1, Peter Stenvinkel

  • 1Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital at Huddinge, Karolinska Institutet, SE 141 86 Stockholm, Sweden.

Nature Reviews. Nephrology
|February 1, 2011
PubMed

Insights

New findings from 2010 trials offer improved management strategies for predialysis chronic kidney disease (CKD). Nephrologists can now better slow CKD progression by focusing on blood pressure, acidosis, and uric acid levels.

Area of Science:

  • Nephrology
  • Internal Medicine
  • Clinical Trials

Background:

  • Chronic kidney disease (CKD) management requires ongoing research to identify effective strategies.
  • Predialysis CKD patients benefit from interventions aimed at slowing disease progression.

Purpose of the Study:

  • To summarize novel findings from 2010 trials regarding predialysis CKD management.
  • To highlight key therapeutic targets for slowing CKD progression.

Main Methods:

  • Review of clinical trials published in 2010 focusing on predialysis CKD.
  • Analysis of data related to blood pressure control, acidosis, and serum uric acid levels.

Main Results:

  • Several 2010 trials provided significant new information on managing predialysis CKD.
  • Targeting specific factors can effectively slow the progression of CKD.

Conclusions:

  • Nephrologists can utilize recent trial data to optimize predialysis CKD patient care.
  • Blood-pressure control, acidosis management, and serum uric acid reduction are key strategies to slow CKD progression.

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