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Updated: Jun 4, 2026

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice
Published on: August 2, 2024
Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory
Andrew J Murray1, Jonas-Frederic Sauer, Gernot Riedel
1Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK.
Abstract:
Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.
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