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Updated: Jun 4, 2026

A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy
Published on: January 30, 2019
Measurement of pH by NMR Spectroscopy in Concentrated Aqueous Fluoride Buffers
1Department of Chemistry, University of Wisconsin-Madison, 1101 University Ave, Madison WI USA 53706-1322.
Abstract:
An NMR spectroscopic technique has been developed to give rapid, accurate pH measurements on tenth-milliliter samples of concentrated acidic aqueous solutions buffered by fluoride ion in the pH 1.5 - 4.5 range. The fluoride (19)F chemical shift has been calibrated as a function of pH at 0.1 and 1.0 M concentration by reference to an internal 3-fluoropyridine standard. Subsequent measurements of fluoride buffer pH required no additives and only two NMR spectra in the presence of an external reference standard.
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