Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Orienting reaction in therapy-resistant generalized epilepsy.

R Rogozea1, V Florea-Ciocoiu, D Haţegan

  • 1Institute of Neurology and Psychiatry, Bucharest, Romania.

Romanian Journal of Neurology and Psychiatry = Revue Roumaine De Neurologie Et Psychiatrie
|July 1, 1990
PubMed
Summary

Epilepsy patients with therapy-resistant generalized seizures exhibit heightened orienting reactions. Antiepileptic drug treatment can improve these interictal responsiveness disturbances, suggesting nervous system excitability issues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The therapy by ischemic stress induces a durable EEG synchronization in alpha frequency band.

Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie·1995
Same author

Amino acid content of the brain in rats focal penicillin induced epilepsy.

Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie·1995
Same author

Habituation of orienting reaction in therapy-resistant partial epilepsy.

Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie·1995
Same author

Increased susceptibility to audiogenic seizures following withdrawal of progesterone.

Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie·1994
Same author

The cerebral content of excitatory and inhibitory amino acids in rats following withdrawal of antiepileptic drugs.

Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie·1994
Same author

Interictal responsiveness in therapy-resistant partial epilepsy.

Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie·1993

Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Psychophysiology

Background:

  • Epilepsy is characterized by recurrent seizures, often associated with altered nervous system excitability.
  • Understanding interictal (between seizures) physiological responses is crucial for managing therapy-resistant generalized seizures (TRGS).

Purpose of the Study:

  • To investigate the orienting reaction components in individuals with TRGS compared to control groups.
  • To identify factors influencing responsiveness disturbances in TRGS patients.
  • To evaluate the impact of antiepileptic treatment on interictal responsiveness.

Main Methods:

  • Polygraphic recordings of somatic, autonomic, and EEG responses to auditory stimuli.
  • Comparison of 39 TRGS patients with two control groups (119 subjects total).

Related Experiment Videos

  • Correlation and multivariate regression analyses to determine predictive variables for responsiveness disturbances.

    • Main Results:

    • Epileptics with TRGS showed significantly heightened orienting reactions compared to normal subjects and therapy-controlled epilepsy patients.
    • Responsiveness disturbances correlated with patient age, seizure type, pretrial seizure frequency, EEG type, and antiepileptic drug regimen (number, dose, serum level).
    • Multivariate analysis identified pretrial seizure frequency, seizure type, drug dose, and serum level as key predictors.

    Conclusions:

    • Therapy-resistant generalized seizures are associated with interictal hyperresponsivity, likely due to nervous system excitability disturbances.
    • Antiepileptic treatment demonstrates a positive effect on these responsiveness disturbances, with sustained treatment yielding greater improvement.
    • These findings highlight the potential for targeting excitability modulation in epilepsy management.