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Schizophrenia is a major public health problem, mainly because of its prevalence and the medical and social costs it generates. Because of his privileged position with the patient, the family physician is often requested not only to provide care but also to give the patient some orientation and support regarding his future and his daily problems. After reviewing some important factors generating handicaps from the disease, treatment and reactions to treatment, this paper aims to give the family physician some answers he can give when facing more specific problems, such as whether to tell the diagnosis, family reactions, motor vehicle driving, work and studies, sexual and marital life, procreation and divorce.