Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Hearing01:31

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Faulty ephedrine prefilled polypropylene syringe.

Anaesthesia·2017
Same author

A case of severe necrotising pancreatitis following ampullary biopsy.

Annals of the Royal College of Surgeons of England·2015
Same author

Age is not a disease.

Canadian family physician Medecin de famille canadien·2011
Same author

Gee, thanks!

Canadian family physician Medecin de famille canadien·2011
Same author

Lentiviral vectors with amplified beta cell-specific gene expression.

Gene therapy·2009
Same author

IL-6-174G/C genotype is associated with the bone mineral density response to oestrogen replacement therapy in post-menopausal women.

European journal of applied physiology·2004
Same journal

Impact of virtual case conferences between primary care clinicians and an interdisciplinary chronic pain clinic.

Canadian family physician Medecin de famille canadien·2026
Same journal

Canadian family physician Medecin de famille canadien·2026
Same journal

Predictors of high-performing family medicine clinics: Prospective cohort study in Alberta.

Canadian family physician Medecin de famille canadien·2026
Same journal

Acetylsalicylic acid use for artial fibrillation and bleeding risk.

Canadian family physician Medecin de famille canadien·2026
Same journal

Clinical practice guidelines: Important tools to teach the art of medicine.

Canadian family physician Medecin de famille canadien·2026
Same journal

Paratonia in advanced dementia: Challenges and evidence-based interventions.

Canadian family physician Medecin de famille canadien·2026
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

Hearing impairment in the elderly.

D Skelton

    Canadian Family Physician Medecin De Famille Canadien
    |February 1, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Age-related hearing loss is common but not inevitable, influenced by aging neurons and environmental factors. Understanding its causes and implications is crucial for the elderly and healthcare systems.

    More Related Videos

    Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae
    08:25

    Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae

    Published on: April 21, 2022

    Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R
    06:01

    Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

    Published on: December 9, 2022

    Related Experiment Videos

    Last Updated: Jun 4, 2026

    Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
    09:09

    Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

    Published on: April 11, 2025

    Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae
    08:25

    Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae

    Published on: April 21, 2022

    Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R
    06:01

    Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

    Published on: December 9, 2022

    Area of Science:

    • Gerontology
    • Audiology
    • Neuroscience

    Background:

    • Hearing impairment frequently accompanies aging, impacting the elderly's quality of life.
    • Both natural neuronal decline and environmental factors contribute to age-related hearing loss.
    • Difficulty with high-frequency sounds and sound localization are common in older adults.

    Purpose of the Study:

    • To highlight the prevalence and implications of hearing loss in the elderly.
    • To underscore the need for greater understanding of hearing handicaps.
    • To inform healthcare professionals and systems about this growing issue.

    Main Methods:

    • Review of current understanding of age-related hearing impairment.
    • Analysis of contributing factors, including neuronal changes and environment.
    • Examination of social and psychological consequences for the elderly.

    Main Results:

    • Elderly individuals experience particular difficulty with high-pitched sounds and focusing on auditory stimuli.
    • Hearing loss in the elderly is linked to significant, often correctable, psychological issues.
    • There is a notable lack of comprehensive understanding regarding the causes, prevalence, and impact of hearing loss in this demographic.

    Conclusions:

    • Age-related hearing impairment is a multifaceted issue with significant social and psychological consequences.
    • Further research is essential to address the limited understanding of hearing handicaps in the elderly.
    • Improved knowledge is vital for effective management by healthcare professionals and the healthcare system.