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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Classification of Leukocytes01:30

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:

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Related Experiment Video

Updated: Jun 4, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

Adult leukemias.

L K Moore

    Canadian Family Physician Medecin De Famille Canadien
    |February 1, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Recent advancements in adult leukemia diagnosis and therapy have significantly improved patient outcomes, particularly for acute nonlymphoblastic leukemias. This article details key clinical, laboratory, and diagnostic strategies, alongside treatment and prognosis for various leukemia types.

    More Related Videos

    Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
    09:57

    Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

    Published on: March 5, 2018

    Assessment of the Metabolic Profile of Primary Leukemia Cells
    06:21

    Assessment of the Metabolic Profile of Primary Leukemia Cells

    Published on: November 21, 2018

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    Last Updated: Jun 4, 2026

    Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
    09:01

    Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

    Published on: March 26, 2018

    Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
    09:57

    Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

    Published on: March 5, 2018

    Assessment of the Metabolic Profile of Primary Leukemia Cells
    06:21

    Assessment of the Metabolic Profile of Primary Leukemia Cells

    Published on: November 21, 2018

    Area of Science:

    • Hematology
    • Oncology
    • Internal Medicine

    Background:

    • Adult leukemias encompass a range of hematologic malignancies.
    • Significant progress has been achieved in understanding and managing these conditions.
    • Improvements in treatment have enhanced patient quality of life.

    Purpose of the Study:

    • To review recent advances in the classification, diagnosis, and therapy of adult leukemias.
    • To highlight the importance of clinical and laboratory diagnostic tests.
    • To describe the therapy and prognosis for different types of leukemia.

    Main Methods:

    • Review of current literature and clinical practices.
    • Emphasis on diagnostic criteria and testing modalities.
    • Discussion of therapeutic approaches and outcome predictions.

    Main Results:

    • Advances have led to improved overall prognosis and quality of life.
    • Acute nonlymphoblastic leukemias show particular benefit from recent therapeutic gains.
    • Key diagnostic tests are crucial for accurate leukemia classification.

    Conclusions:

    • Modern approaches to adult leukemia have markedly improved patient outcomes.
    • Comprehensive diagnostic evaluation is essential for effective treatment planning.
    • Continued research is vital for further enhancing leukemia therapy and prognosis.