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Updated: Jun 4, 2026

A Rat Model of Compound Acne
Published on: November 1, 2024
Isotretinoin use in severe acne
Abstract:
Isotretinoin, an oral vitamin A derivative, is highly effective in, and at present indicated only for, the treatment of cystic acne, conglobate acne, or severe acne which has failed to respond to conventional therapy, including systemic antibiotics. Isotretinoin use usually results in a prolonged remission, often with complete disappearance of previously resistant lesions. Virtually all patients experience reversible integumentary side effects, which can almost always be controlled with emollients or lubricants. Isotretinoin is a known teratogen. The longterm effects of the transient vitamin A imbalance produced by this medication are not yet known.
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ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
