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Gastroprotective effect of Benincasa hispida fruit extract
Manish A Rachchh1, Sunita M Jain
1Department of pharmacology, S. J. Thakkar Pharmacy College, Rajkot, Gujarat, India.
Indian Journal of Pharmacology
|February 1, 2011
Summary
Benincasa hispida fruit extracts show significant antiulcer activity in rat models. These natural compounds effectively reduce gastric damage and possess antioxidant properties, offering potential therapeutic benefits.
Area of Science:
- Pharmacology
- Natural Product Chemistry
- Gastroenterology
Background:
- Peptic ulcers are a common gastrointestinal disorder.
- Benincasa hispida (Thunb.) Cogn. is a plant with traditional medicinal uses.
- Evaluating the scientific basis for its antiulcer properties is warranted.
Purpose of the Study:
- To investigate the antiulcer activity of Benincasa hispida fruit extracts.
- To assess the efficacy against ethanol-induced gastric mucosal damage, pylorus ligated (PL) ulcers, and cold restraint-stress (CRS) ulcers in rats.
- To evaluate the antioxidant potential of the extracts.
Main Methods:
- Oral administration of petroleum ether and methanol extracts (300 mg/kg) and omeprazole (20 mg/kg) to rats.
- Assessment of ulcer index in all models.
- Evaluation of vascular permeability in the ethanol model.
- Measurement of malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) levels in the CRS model.
Main Results:
- Both extracts significantly reduced the ulcer index in all tested models (P < 0.05).
- Results were comparable to the omeprazole-treated group.
- Significant reduction in vascular permeability and malondialdehyde (MDA) content was observed.
- Increased catalase (CAT) levels were noted in the CRS model.
Conclusions:
- Petroleum ether and methanol extracts of Benincasa hispida demonstrate significant antiulcer properties.
- The extracts exhibit notable antioxidant activity.
- Benincasa hispida fruit extracts show promise as a natural remedy for gastric ulcers.
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