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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
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Label-free cell-based assays using photonic crystal optical biosensors.

Steven M Shamah1, Brian T Cunningham

  • 1Director of Cell Biology, SRU Biosystems, Woburn, MA, USA.

The Analyst
|February 1, 2011
PubMed
Summary

Label-free biosensor technology enables real-time, non-destructive monitoring of cell behavior in culture. This approach offers a powerful new tool for cell-based assays, including high-throughput screening of stem cells.

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Last Updated: Jun 4, 2026

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
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Published on: February 10, 2014

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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Biosensor Technology

Background:

  • Biosensors, initially for biomolecular interactions, now advance cell-based assays.
  • Label-free biosensors offer non-destructive, long-term cell monitoring.
  • Traditional methods like microscopy lack temporal resolution for cell-surface interactions.

Purpose of the Study:

  • To review the application of photonic crystal optical biosensor microplates in cell-based assays.
  • To highlight the advantages of label-free biosensing for quantitative cell monitoring.
  • To discuss advancements in biosensor detection for population and single-cell analysis.

Main Methods:

  • Utilizing photonic crystal optical biosensor microplates for cell attachment monitoring.
  • Employing label-free detection to avoid cell death and photobleaching.
  • Applying temporal monitoring of cellular processes like proliferation and apoptosis.

Main Results:

  • Biosensors provide unique temporal data on integrin-surface interactions.
  • Label-free systems allow quantitative, extended monitoring of cell behavior.
  • Photonic crystal biosensors can assess aggregate or individual cell responses.

Conclusions:

  • Biosensor technology revolutionizes cell-based assays by enabling label-free, real-time monitoring.
  • Photonic crystal biosensors offer versatile applications, from basic research to high-throughput screening.
  • Advancements in detection support assays with limited cell numbers, crucial for stem cell research.