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[Effects of glycine on auditory evoked potentials among diabetic patients with auditory pathway neuropathy]
María de Lourdes Muñoz-Carlin1, José Raymundo Rodríguez-Moctezuma, Juan Gerardo Gómez Latorre
1Hospital General Regional 72, Tlalnepantla, México. malourdes_255@yahoo.com.mx
Background:
Glycine inhibits the formation of advanced glycation end products that may cause central and peripheral neuronal damage, affecting also the auditory nerve.
Aim:
To evaluate the effect of glycine on auditory nerve conduction and hearing level among patients with type 2 diabetes mellitus and auditory neuropathy.
Material And Methods:
Twenty grams of oral glycine per day were administered during 6 months to 28 type 2 diabetic patients aged 58 ± 6 years, with auditory pathway neuropathy. Hearing tests and evoked otoacustic potentials were performed regularly. Fifteen diabetic patients aged 49 ± 8 years, without auditory nerve neuropathy did not receive glycine and were followed as a control group.
Results:
Among patients receiving glycine, a significant improvement in left ear audiometry at 125, 250 and 500 Hz and right ear audiometry at 500 Hz, was observed. Waves I, III and V (p= 0.02) of evoked otoacustic potentials improved significantly in the left ear and wave I in the right ear. Among controls, waves V and III of evoked otoacoustic potentials had a significant impairment in the left ear.
Conclusions:
There was an improvement in auditory evoked potentials in patients receiving glycine and an impairment in untreated control patients.
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