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Mechanism of cardioprotection: what can we learn from females?
Elizabeth Murphy1, Claudia Lagranha, Anne Deschamps
1NHLBI, NIH, Room 8N202, Building 10, 10 Center Drive, Bethesda, MD, USA. murphy1@mail.nih.gov
Pediatric Cardiology
|February 1, 2011
Abstract:
This review examines the mechanism of estrogen signaling in cardiomyocytes, with an emphasis on mechanisms that might be important in cardioprotection. It investigates estrogen signaling mediated by the nuclear estrogen receptors alpha and beta and the G-protein-coupled receptor (GPR 30/GPER). Estrogen signaling via nitric oxide and the PI3K pathway are discussed.