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Visual field loss in children with craniosynostosis

Alki Liasis1, Bronwen Walters, Dorothy Thompson

  • 1The Clinical and Academic Department of Ophthalmology, Great Ormond St Hospital for Children, London, UK.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|February 1, 2011
PubMed

Insights

Children with syndromic craniosynostosis exhibit visual field deficits, varying by syndrome type. These deficits indicate visual dysfunction beyond central vision testing, highlighting the need for comprehensive ophthalmic evaluations.

Area of Science:

  • Ophthalmology
  • Genetics
  • Pediatrics

Background:

  • Syndromic craniosynostosis involves premature fusion of cranial sutures, potentially impacting neurodevelopment and visual pathways.
  • Ocular complications are common in syndromic craniosynostosis, necessitating thorough visual assessments.

Purpose of the Study:

  • To investigate and characterize visual field deficits in children diagnosed with syndromic craniosynostosis.
  • To correlate specific visual field abnormalities with different types of syndromic craniosynostosis.

Main Methods:

  • Kinetic visual field examinations were performed on 16 children with syndromic craniosynostosis.
  • Visual evoked potentials (VEPs) were recorded to assess visual pathway function and inter-hemispheric symmetry.

Main Results:

  • All evaluated children presented with visual field deficits compared to normative data.
  • Specific patterns of visual field loss were observed, including nasal deficits in Crouzon syndrome and infero-nasal deficits in Apert syndrome.
  • Pfeiffer syndrome cases showed the most severe and widespread visual field constrictions; VEPs indicated abnormalities in a majority of patients.

Conclusions:

  • Visual field deficits are a consistent finding in syndromic craniosynostosis, suggesting significant visual dysfunction.
  • The type and severity of visual field loss appear to correlate with specific genetic syndromes.
  • Standard central vision tests may not detect these peripheral visual field impairments, underscoring the importance of specialized ophthalmic evaluations.
Abstract

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